Professor CG Caro
Imperial College London
Royal School of Mines
London SW7 2AZ
Tel: +44 (0)207 594 5180
Fax: +44 (0)207 594 9817
Email: c.caro@imperial.ac.uk

Research Intro

Circulatory Fluid Mechanics Group

Certain diseases, including atherosclerosis, which causes heart attack and stroke, and intimal hyperplasia, which can block arterial stents and bypass grafts, and other interventions, affect particular locations in blood vessels. The group’s research is principally directed to determining the mechanisms underlying the local occurrence of the diseases, to early detection of their onset and, in some instances, to suppression of their causation.


Helical stent designed by Professor CG Caro

Research Topics and Selected Papers

Atherosclerosis and wall shear

Caro, C.G. Fitz-Gerald, J.M. and Schroter, R.C. (l969). Arterial wall shear and distribution of early atheroma in man. Nature 223, ll59-ll6l.

---

Non-planar geometry in arteries

Caro, C.G., Doorly, D.J., Tarnawski, M., Scott, K.T., Long, Q. and Dumoulin, C.L. (1996). Non-planar curvature and branching of arteries and non-planar-type flow. Proc. Roy. Soc. A. 452, 185-197.

---

Helical arterial stents

Shinke, T., et al (2008). Novel helical stent design elicits swirling blood flow pattern and inhibits neointima formation in porcine carotid arteries. Circulation 118:S_1054.

---

Flow and mass transport in non-planar geometries

Coppola, G. and Caro, C.G. (2009). Arterial geometry, flow pattern, wall shear and mass transport: potential physiological significance. J. R. Soc. Interface, 6, 519-528

Curriculum Vitae

EMERITUS PROFESSOR COLIN G CARO
Department of Bioengineering, Imperial College London
Royal School of Mines Building, SW7 2AZ
Tel: 0207 594 5180 (work); Fax: 0207 594 9817
Email: c.caro@imperial.ac.uk
dob: 3rd Oct, 1925

Present Appointments
Emeritus Professor of Physiological Mechanics and Senior Research Investigator, Department of Bioengineering, Imperial College 1991-
Member Steering Committee, Cardiovascular Technology Network, Imperial College Institute of Biomedical Engineering 2005-
Founder and Research Director, Imperial College Spin-Out Company, Veryan Medical Limited 2004-
Founder and Research Director, Imperial College Spin-Out Company, HeliSwirl Technologies Limited 2005-
Member Advisory Board, Imperial College Imaging Science Centre 2006-


Previous Appointments
Chairman, Cardiovascular Technology Network, Imperial College Institute of
Biomedical Engineering 2005-06
Chairman, Advisory Board, Imperial College Imaging Science Centre 2003-06
Chairman, Steering Committee, Imperial College Imaging Science Centre 2001-03
Director, Centre for Biological and Medical Systems, Imperial College 1989-91
Founder and Director, Physiological Flow Studies Unit, Imperial College 1966-89


Degrees/Honours
B.Sc. Hons. (Witwatersrand) 1949
M.B., B.Ch. (Witwatersrand) 1950
M.R.C.P. (Edinburgh) 1954
M.D. (Witwatersrand) 1961
F.R.C.P. (Edinburgh) 1968
F.R.C.P., Byelaw 39d (London) 1992
D.Sc (Engineering), Honoris Causa (London) 2003
Docteur, Honoris Causa (University of Paris XII) 2005
D.Sc (Engineering), Honoris Causa (Witwatersrand) 2010


Royal Society Visiting Research Professor, Weizmann Institute, Israel 1978
Tokyo Women's Medical College (First Awardee Invited Professorship) 1981
American Institute of Medical & Biological Engineering (Initial Awardee Foreign Fellowship) 1994
International. Academy of Medical & Biological Engineering (Founding Fellow) 2000
Institute of Physics and Engineering in Medicine (Honorary Fellowship) 2002
International Society of Cardiovascular Medicine and Science (Arthur Guyton Award) 2003
Caro Research Studentship, created by Department of Bioengineering, Imperial College 2007
Colin Caro Award for Most Meritorius Student in Bioengineering, created by University of Witwatersrand, Johannesburg 2007
Winner, The Engineer Outstanding Achievement Award, The Engineer Technology and Innovation Awards 2007


Learned Societies
British Atherosclerosis Society
The Physiological Society
Medical Research Society
American Physiological Society
British Microvascular Society
International Society of Biorheology (former Vice President)
World Congress of Biomechanics (former Chairman International
Steering Committee)
American Institute for Medical and Biological Engineering
International Academy for Medical and Biological Engineering
Institute of Physics and Engineering in Medicine


Evidence of Esteem
Over 250 Peer Reviewed papers
Over 96 Invited Lectures to National & International institutions
2 Books Authored, 4 Books Edited and numerous contributions to books by others


Representative Publications
Coppola, G. and Caro, C.G. (2009). Arterial geometry, flow pattern, wall shear and mass transport: potential physiological significance. J. R. Soc. Interface, 6, 519-528.

Caro, C.G. (2009). Discovery of the role of wall shear in atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology 29, 158-161.

Smouse, H.B., Shinke, T., Mullins, L., O’Brien, N., Heraty, K., Burke, M.G., Taylor, C., Gilson, P., Robinson, K., Cheshire, N.J., Caro C.G. (2008). Helical Stent Design Elicits Spiral Blood Flow Pattern and Inhibits Neointima Formation In Porcine Carotid Arteries. Veith Symposium, New York, 19-23 November

Coppola, G. and Caro, C.G. (2008). Oxygen mass transfer in a model three-dimensional artery. J. R. Soc. Interface 5, 1067-1075.

Caro, C.G., Doorly, D.J., Tarnawski, M., Scott, K.T., Long, Q. and Dumoulin, C.L. (1996). Non-planar curvature and branching of arteries and non-planar-type flow. Proc. Roy. Soc. A. 452, 185-197.

Caro, C.G., Fitz-Gerald, J.M. and Schroter, R.C. (l97l). Atheroma and arterial wall shear. Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis. Proc. Roy.Soc. B l77, l09-l59.

Caro, C.G. Fitz-Gerald, J.M. and Schroter, R.C. (l969). Arterial wall shear and distribution of early atheroma in man. Nature 223, ll59-ll6l.

Benefits

Requirements

Bioengineering Research Imperial College London