Guy-Bart STAN's research webpage


Who am I? | Selected Publications | Research interests | CV | Openings | How to contact me? | Group members | Books | Full list of Publications | Presentations | Lecture Notes | Latest bookmarked papers and links to interesting websites | Ph.D. Thesis | Master's Thesis


Guy-Bart Stan

Who am I?

My name is Guy-Bart STAN. I was born in Liège, Belgium, in 1977. I received my electrical (electronics) engineering degree in June 2000 and my Ph.D. degree in March 2005, both from the University of Liège. I am a permanent academic member of staff in the Department of Bioengineering and the head of the Control Engineering Synthetic Biology group in the Centre for Synthetic Biology and Innovation of Imperial College London (U.K.). From August 2010 until September 2011, I was one of the organisers for the weekly Bioengineering Departmental Seminars.

From January 2006 until December 2009, I worked in the Control Group of the University of Cambridge (U.K.) as a Research Associate with support from EPSRC (EP/E02761X/1) for the period January 2007 - January 2010 and support from a European Commission FP6 Marie-Curie Intra-European Fellowship (EU FP6 IEF 025509 GASO) for the period January 2006 - January 2007. From January 2006 until December 2009, I was the weekly seminar organiser for the Cambridge University Control Group. Current and past seminars at the Cambridge University Control Group are accessible online via talks.cam. From June to December 2005, I worked as Senior DSP Engineer at Philips Applied Technologies. Until May 2005, I worked in the Nonlinear Systems and Control group at the Systems and Modeling research unit of the University of Liège with F.N.R.S. (Belgian National Fund for Scientific Research) support.

My webpage in the Department of Bioengineering of Imperial College London (U.K.).

My webpage in the Control Group of the University of Cambridge (U.K.).

I am the recipient of the prestigious EPSRC Engineering Fellowship for Growth from 2015 to 2020. I am also a Chartered Engineer (IET CEng) and a member of the The Institution of Engineering and Technology (The IET) and the The Institute of Electrical and Electronics Engineers (The IEEE).


Selected Publications


Research interests

I am passionate about developing new concepts and methods and applying the produced results to real-life problems. Currently, my main research interests are: Nonlinear Dynamical Systems Analysis and Control, Synthetic Biology, Systems Biology.

If you want a short introduction to some of the work we are looking at in my group please have a look at this 15 min short interview by Faculti Media about one of our projects: Synthetic Biology Genetic Control Circuits for Robust and Efficient Metabolic Pathways.

I am currently interested in the modelling, analysis and control of complex biological networks (in particular control of collective behaviours in cell populations, consensus, synchronisation, analysis and design of oscillator networks); and in applications of control theory concepts and reinforcement learning methods to the problem of robustly and optimally controlling natural or synthetic biological systems, e.g., optimal robust control of gene regulation networks or optimal drug cocktails scheduling for chronic-like diseases treatments (e.g. cancer and HIV).


Curriculum Vitae

You can download a pdf version of my CV here.

For a visual timeline of my career you can follow this link on Vizualize.me.

For a citations report of my published papers you can follow this link on Google Scholar Citations or this link on ResearchGate.


Openings

Join the Stan Group

We have two PostDoctoral positions opening-up soon (one to start in Jan 2015 and one to start in Jan 2017).

If you are a highly motivated and dynamic post-doc with experience in synthetic biology and are looking to join one of the fastest-growing synthetic biology groups in the world (with all the best toys), please email us with your CV as soon as possible.

ADVERT: Expression of Interest

General information about us

Interested in working with me in synthetic/systems biology at the Department of Bioengineering of Imperial College London? Please visit our group openings website for openings in the Stan Group or the CSynBI hiring page for opportunities in our centre. Hereafter, you will find interesting links which provide you with information about openings and how to apply.

List of PostDoctoral Fellowships

If you would like to apply for a PostDoctoral Fellowship to work in my group, you might want to have a look at this list of funded PostDoctoral Fellowships.

Also, Nick Jones has compiled a list of fellowships that you might also want to consider.

PhD Openings

Information about the Imperial College PhD Scholarship scheme is available here and here. Furthermore, Ph.D. studentships in the Department of Bioengineering are advertised here. Information about the PhD programme in the Department of Bioengineering and how to apply can be found here. For general information on the tuition fees and cost of living in London, please read this link. For other sources of funding you can also look at the main general link here and here (BioEngineering funding) and here (fees and financial help).

Please check the College entry requirements carefully before applying.

From the prospective Bioengineering PhD student weppage you can download the Research Student Handbook which has some advice on where to apply for conference money (in the "Useful Links" section).


How to contact me?

Dr Guy-Bart Stan
Centre for Synthetic Biology and Innovation (CSynBI),
Department of Bioengineering at Imperial College,
703 Bessemer Building, Imperial College London,
South Kensington Campus, London SW7 2AZ, United Kingdom

E-mail:              g.stan "(at)" imperial.ac.uk
Office phone:    +44(0)207 59 46375

Group members

The current list of group members is available at the people section of our group website.

For more information about the various students I have supervised see the Supervisory Experience section of my CV.


Books

Synthetic Biology: a Primer

Synthetic Biology: a Primer, G. Baldwin, T. Bayer, R. Dickinson, T. Ellis, P. Freemont, R. Kitney, K. Polizzi, N. Rose, G.-B. Stan, Imperial College Press, August 2012, ISBN-10: 1848168624, ISBN-13: 978-1848168626.

A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations

A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations, Eds.: V. Kulkarni, G.-B. Stan, K. Raman, Springer, July 2014, ISBN: 978-94-017-9040-6 (Print), 978-94-017-9041-3 (Online). Click here for amazon.co.uk link.

A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems

A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems, Eds.: V. Kulkarni, G.-B. Stan, K. Raman, Springer, July 2014, ISBN: 978-94-017-9046-8 (Print), 978-94-017-9047-5 (Online). Click here for amazon.co.uk link.


Full list of Publications

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

2002

2001

  • Determination of the Scattering Coefficient of Random Rough Diffusing Surfaces for Room Acoustics Applications, J.-J. Embrechts, D. Archambeau, G.-B. Stan, Acta-Acoustica Acoustica, Volume 87 (2001), n° 4 pp. 482-494.

Internal Reports

  • Comparison of Algorithms for Biological Network Reconstruction from Data, Openwetware webpage of Nuri Purswani as part of her MSc project with me in 2010.
  • Global Analysis of Limit Cycles in the Chua System, Internal report, Cambridge University, UK, April 2006, available upon request.
  • Dissipativity and Global Analysis of Limit Cycles, Internal Report, Montefiore, Ulg, 2004, available upon request.

Selected Presentations


Lecture Notes


Latest bookmarked papers and links to interesting websites

List of papers on CiteULike.

Imperial's 2013 iGEM team - Plasticity (Supervisor on the modelling side of the project)

Imperial's 2011 iGEM team - Auxin (Supervisor on the modelling side of the project)

Imperial's 2010 iGEM team - Parasight (Supervisor on the modelling side of the project)


Ph.D. Thesis

The title of my Ph. D. thesis is Global analysis and synthesis of oscillations: a dissipativity approach.

Abstract:

The main theme of this research concerns the global (as opposed to local) analysis of stable limit cycle oscillations in dynamical systems. The global analysis of oscillations in systems and networks of interconnected systems is a longstanding problem. Dynamical systems that exhibit robust nonlinear oscillations are called oscillators. Oscillators are ubiquitous in physical, biological, biochemical, and electromechanical systems. Detailed models of oscillators abound in the literature, most frequently in the form of a set of nonlinear differential equations whose solutions robustly converge to a limit cycle oscillation. Local stability analysis is possible by means of Floquet theory but global stability analysis is usually restricted to simple (second order) models. For these simple models, global analysis is performed by using specific low dimensional tools (phase plane methods, Poincaré-Bendixson theorem, etc.) which do not generalise easily to complex (high dimensional) models. As a consequence, global analysis of complex models is quite hard since there currently exists no general analysis method. This lack of general analysis methods typically forces complex models of oscillators to be studied only through numerical simulation methods. Although numerical simulations of these models may give a first insight into their behaviour, a more in-depth understanding is generally impeded by the complexity of the models and the challenge of rigorous global stability analysis. Moreover, even in the case of simple models, the low dimensional methods used for the analysis do not generalise to the analysis of a network of interconnected oscillators. These considerations show the need for developing general methods that allow the global analysis of oscillators, either isolated or in interconnection. This thesis constitutes the first step towards the development of such a unified oscillators theory. In this aim, this thesis considers an extension of the dissipativity theory introduced by Willems. Nowadays, dissipativity is considered as one of the most general nonlinear (global) stability analysis method for equilibrium points in dynamical systems and networks of interconnected dynamical systems. In this thesis, we show that dissipativity theory can be extended to allow (global) stability analysis of limit cycles in many Lure-type models of oscillators and networks of oscillators. These Lure-type models of oscillators have been named passive oscillators. As the main results of this research, we have showed the implications of this extended dissipativity theory for

  • the global stability analysis of isolated passive oscillators
  • the global stability analysis of networks of passive oscillators
  • the global stability analysis of synchronised oscillations in networks of identical passive oscillators

Furthermore, based on these results, we also propose a limit cycle oscillations synthesis method based on the design of a nonlinear parametric proportional-integral controller aimed at the generation of limit cycle oscillations with large basin of attraction in stabilisable nonlinear systems.

You can download here a summary of my (Ph.D.) F.N.R.S. research project Research.pdf (in french).


Master's Thesis

The translated title of my master thesis is Creation of an autonomous impulse response measurement system for rooms and transducers with different methods - "Réalisation d'une chaine de mesure autonome de la réponse impulsionnelle de salle selon différentes méthodes" (the manuscript is in french).

Abstract:

In this research, we compare four of the most used impulse response measurement techniques: Maximum Length Sequence (MLS), Inverse Repeated Sequence (IRS), Time Stretched Pulses, and Logarithmic Sinesweep. These methods are generally used for the measurement of the impulse response of acoustical systems such as transducers, rooms, and binaural impulse responses. The choice of one of these methods depending on the measurement conditions is critical. Therefore an extensive comparison has been realised. This comparison has been done through the implementation and realisation of a complete, fast, reliable, and cheap measurement system. In particular, these different methods have been compared with respect to best achievable signal-to-noise ratio, ease of use, harmonic distortion rejection/measurement, and robustness to measurement conditions (temperature change, impulsive and white noise, etc.). It is shown that in the presence of non white noise, the MLS and IRS techniques are more appropriate. On the contrary, in quiet environments the Logarithmic Sinesweep method is the most accurate: it allows for a direct improvement of the signal-to-noise ratio of 30 dB over the other methods, which can be critical for audio virtual reality systems such as auralization systems. Indeed, capturing binaural room impulse responses for high-quality auralization purposes requires a signal-to-noise ratio of more than 90 dB which is unattainable with other measurement techniques due to inherent nonlinearities in the measurement system (especially the loudspeaker), but fairly easy to reach with logarithmic sinesweeps due to the possibility of completely rejecting (and measuring) harmonic distortions. As a consequence, the sinesweep method opens the way for the development of high-quality auralization and sound spatialisation systems which constitute the bases for advanced audio virtual reality systems.


Last updated: 2013-10-10

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