Martin Boutelle
Martin Boutelle
m.boutelle@imperial.ac.uk
RSM 3.14
Department of Bioengineering
Imperial College London
London SW7 2AZ
Tel: +44 207 594 5138

Research Intro

Biomedical sensors group

My biomedical monitoring research group is multidisciplinary, embracing both the development of fundamental physical/ analytical science methods and the use of these new techniques in a programme of neuroscience and clinical science research. My approach is to combine real-time measurement of neurochemical, electrical and physical measurements such as blood flow and local brain pressure to give a clear picture of the dynamics of tissue response to stimulation or trauma. The same measurement techniques are used in patients and in experimental models allowing genuine translational research.

 

Research Topics and Selected Papers


Measurement methodologies

  • Tissue Sampling
    • Real-time microdialysis
    • Microfabricated microdialysis sampling probes
    • ‘Smart’ catheters and drains
    • Digital microfluidics - microfabricated flow-segmentation devices for microdialysis
  • Detection of molecular biomarker
    • Ion selective electrodes
    • Microelectrode based biosensors
    • Design of low noise computerised instrumentation
    • Noise reduction algorithms
    • low volume on-line flow cells for digital microfluidics
  • Measurement for other tissue signals
    • Measurement of brain electrical activity - electrocoticography , full band EEG
    • Measurement of local blood flow using laser speckle methods
    • Data fusion from different real-time measurement techniques

 


Clinical and neuroscience research

  • Clinical detection and characterisation of spontaneous electrical depolarisation waves in traumatic brain injury patients.
  • Clinical monitoring of neurochemistry in brain injury in traumatic brain injury patients
  • Translational study of transient neurochemical mechanisms underlying brain injury
  • Development of energy budgets for neurotransmission
  • Clinical monitoring of ‘at risk’ bowel during and following surgery
  • Development of monitoring system for transplanted kidneys
  • Development of a point of care test for obstetric choliastasis  - a key risk factor for the development of pre-eclampsia in pregnant women

Collaborators

Imperial Collaborators
Professor Andrew de Mello (microfluidics)
Professor Tony Cass (Biorecognition)
Professor Catherine Williamson (Bile acid monitoring)
Professor Lord Ara Darzi (bowel and kidney monitoring)
Professor Geprge Hanna (bowel and kidney monitoring)

National Collaborators
Professor Anthony Strong ( Neurosurgical research, King’s College Hospital)
Dr Clemens Pahl (Intensive care consultant, King’s College Hospital)
Mr Christos Tolias  (Neurovascular surgeon, King’s College Hospital)
Mr Donal Walsh (Neurovascular surgeon, King’s College Hospital)

International Collaborators
Professor Rudolf Graff (Max Planck Institute for Neurophysiology, Cologne)
Professor Martin Lauritzen (Pannum Institute, Copenhagen)
Professor Peter Vaikoczy (Charité Hospital Berlin)

Curriculum Vitae

Previous Posts Held

Reader in Biomedical Sensors engineering

Dec 2004 -

Dept of Bioengineering
Imperial College

Reader in Biomedical Analysis

Sept 2004- Dec 2004

Department of Chemistry, King’s College London

University Lecturer in Physical and Analytical Chemistry

Sept 1996- Sept 2004

Department of Chemistry, King’s College London

E P Abraham Research Fellowship

1990-1994

Green College, University of Oxford

PDRA

 

1992-1996

New Chemistry Laboratory, Oxford
Research working with Prof Allen Hill FRS and
Dr Marianne Fillenz.

PDRA

1984-1992

University Laboratory of Physiology, Oxford
Research working Dr Marianne Fillenz.

Higher education

1980 - 83       

       

PhD, DIC in Physical Chemistry
Supervisor : Prof. W.J. Albery FRS
Thesis Title " The Development of Modified Electrodes"
Imperial College London

1977 - 80

BSc (Hons), ARCS
First Class Degree in Chemistry
Imperial College London

Membership of Professional Bodies,

Member of British Neuroscience Association (1995-)
Member of Society of Electroanalytical Chemistry (2003-)
Member of International Society for Electrochemistry (2005-)
Member of International Society for Monitoring Molecules in Neuroscience (2010-


Martyn Boutelle trained at Imperial College gaining a Ph,D in electrochemistry with John Albery in the Department of Chemistry. He then moved to Physiology at the University of Oxford where he worked with Marianne Fillenz in the interdisciplinary area of in vivo monitoring of the brain using electrochemical sensors. His work there lead to an interest in brain metabolism, and monitoring extracellular neurochemistry with high time resolution by use of microelectrodes and on-line microdialysis. This was extended to clinical monitoring of the brain in 1995 when he moved to the Department of Chemistry, King’s College where he was a Lecturer and then a Reader in Biomedical Analysis.   He now works closely with neurosurgeons at King’s College Hospital,  and bowel surgeons at St Mary’s Hospital on the use of rapid sampling on-line microdialysis to detect transient ischaemia, and the development of new clinical monitoring techniques. He is a founder member of COSBID (www.cosbid.org), an grouping of clinicians and fundamental scientists interested in the role of spontaneous brain depolarisations in the maturation of brain injury.